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Klaus Gerwert

Klaus Gerwert (PI; University of Bochum)

 

Project(s) involved: Gerwert/Herlitze

 

Curriculum vitae Klaus Gerwert

Prof. Dr., 03.05.1956

Fakultät für Biologie und Biotechnologie

Lehrstuhl für Biophysik

NDEF 04/596

Universitätsstr. 150

44780 Bochum, Germany

Phone        +49-0234-32-24461

Email         gerwert@bph.rub.de

website:    http://www.bph.rub.de/

 

Education & Scientific Degrees

1975-1981         Diploma (Physics), University of Münster, Germany, Prof.

1985                  Dr. rer. nat. (Biophysical Chemistry), Albert-Ludwigs-University Freiburg with Prof. Dr. Josef Ackermann, Prof. Dr. Werner Kreuz, Germany

                         

Research Experience

1986-1990         Post-Doctoral Fellow, Max-Planck-Institute, Dortmund, Germany

1990                  „Visiting investigator“, Scripps Research Institute, La Jolla, USA

1990-1993         Heisenberg-Fellow, DFG, Scripps Research Institute, La Jolla, USA, Molecular Biology Department and MPI-Dortmund, Germany

1993                  Habilitation (Physical Chemistry), Bielefeld University, Germany. Mentor: Prof. Dr. Eberhard Neumann

Since 1993        Professor (C4;W3 since 2009) and chairman of the Department of Biophysics, Faculty for Biology and Biotechnology, Ruhr University Bochum, Germany

2008-2013         Director at the Max-Planck Partner Institute for Computational Biology, Shanghai, China

Since 2008        “Max-Planck-Fellow” of the Max-Planck society

                         

Honors & Awards

1990                  Heisenberg fellowship of the Deutsche Forschungsgemeinschaft

1992                  Karl Arnold Jansen Award 1992 of the Rhine-Westphalian Academy of Sciences

2006                  Innovation Award Ruhr 2006, Award of the prime minister of North Rhine-Westphalia, Alfried Krupp von Bohlen and Halbach foundation

2008-present     Member of the North Rhine-Westphalian Academy of Sciences

 

 

Selected Publications

1)     El-Mashtoly, S.F., Yosef, H.K., Petersen, D., Mavarani, L., Maghnouj, A., Hahn, S.A., Kötting, C. and Gerwert, K. (2015) Label-free Raman spectroscopic imaging monitors the integral physiologically relevant drug responses in cancer cells. Anal. Chem. 87, 7297-7304.

2)      Gavriljuk, K., Gazdag, E. M., Itzen, A., Kötting, C., Goody, R. S., Gerwert, K. (2012) Catalytic Mechanism of a Mammalian Rab•RabGAP Complex in Atomic Detail. Proc. Natl. Acad. Sci., 109 (52), 21348-21353.

3)      Rudack, T., Fei X., Schlitter, J., Kötting, C. and Gerwert, K. (2012) Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc. Natl. Acad. Sci. 109, 15295-15300.

4)      Freier, E., Wolf, S. and Gerwert, K. (2011) Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc. Natl. Acad. Sci., 108 (28), 11435-11439

5)      Wolf, S., Freier, E., Potschies, M., Hofmann, E. and Gerwert, K. (2010) Directional Proton Transfer in Membrane Proteins Achieved through protonated Protein-Bound Water Molecules: Angew. Chem. Int. Ed., 49, 6889-6893

6)      Elfrink, K., Ollesch, J., Stöhr, C., Willbold, D., Riesner, D., Gerwert, K. (2008) Structural changes of membrane anchored PrPC. Proc. Natl. Acad. Sci., 105, No. 31, 10815-10819.

7)      Kötting, C., Kallenbach A., Suveyzdis, Y., Wittinghofer, A. Gerwert, K. (2008) The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc. Natl. Acad. Sci., 105, No. 17, 6260-6265.

8)      Garczarek, F., Gerwert, K. (2006) Functional Waters in Protein Proton Transfer. Nature, 439, 109-112.

9)      Remy, A., Gerwert, K. (2003) Coupling of light-induced electron transfer to proton uptake in photosynthesis. Nature Struct. Biol., 10, 637–644.

10)    Brudler, R., Rammelsberg, R., Woo, T.T., Getzoff, E.D., Gerwert, K. (2001) Structure of the I1 early intermediate of photoactive yellow protein by FTIR spectroscopy. Nature Structural Biology, 8, no. 3, 265 – 270.