Skip to main content

Patrick Ruther

Patrick Ruther (PI; University of Freiburg)


Project(s) involved: Diester/Möglich/Ruther/Zurbriggen



Curriculum vitae Patrick Ruther

Dr. ing., born 05.04.1964, 1 child

Address / Affiliation: Department of Microsystems Engineering, University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, +49 761-203 7197,

Akademischer Oberrat (A14)

Academic Education

Physics (10/1987 – 06/1993), University of Constance, Diploma in Physics

Scientific degrees

Promotion: Mechanical Engineering, Technical University of Karlsruhe, 1996, Prof. Dr. W. Menz

Professional experience

09/1996 – 09/1998, Postdoctoral Researcher, Research Centre Karlsruhe, Germany

09/1998 – 09/2004, Groupleader (akademischer Rat), Department of Microsystems Engineering, University of Freiburg

Since 10/2004, Senior scientist and groupleader (akademischer Oberrat), University of Freiburg, Department of Microsystems Engineering

Others experiences, awards

Editorial board member – IEEE Sensors Journal

2006        FAM Förderpreis, Forum Angewandte Mikrosystemtechnik

Ten most important publications

P. Ruther, O. Paul, New approaches for CMOS-based devices for large-scale neural recording, Current Opinion in Neurobiology, 2015, 32, 31-37

N.A. Donnelly, T. Holtzman, P.D. Rich, A.J. Nevado-Holgado, A.B. P. Fernando, G. Van Dijck, T. Holzhammer, O. Paul, P. Ruther, O. Paulsen, T. W. Robbins, and J.W. Dalley Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome, PLoS ONE, 2014, 9, 0111300

C. Gossler, C. Bierbrauer, R. Moser, M. Kunzer, K. Holc, W. Pletschen, K. Köhler, J. Wagner, M. Schwaerzle, P. Ruther, O. Paul, J. Neef, D. Keppeler, G. Hoch, T. Moser, U.T. Schwarz, GaN-based micro-LED arrays on flexible substrates for optical cochlear implants, Journal of Physics D: Applied Physics, 2014, Vol. 47, 205401

S. Seidl, S. Herwik, T. Torfs, H. P. Neves, O. Paul, P. Ruther, CMOS-Based High-Density Silicon Microprobe Arrays for Electronic Depth Control in Intracortical Neural Recording, Journal of Microelectromechanical Systems, vol. 20(11), 2011, doi 10.1109/JMEMS.2011.2167661

S. Spieth, O. Brett, K. Seidl, A.A.A. Aarts, M.A. Erismis, S. Herwik, F. Trenkle, S. Tätzner, J. Auber, O. Paul, H.P. Neves, R. Puers, P. Ruther, R. Zengerle, A Floating 3D Silicon Microprobe Array for Neural Drug Delivery Compatible with Electrical Recording, J. Micromech. Microeng., vol. 21 (2011), 125001 (16pp)

O. Frey, P. D. van der Wal, S. Spieth, O. Brett, K. Seidl, O. Paul, P. Ruther, R Zengerle and N F de Rooij, Biosensor microprobes with integrated microfluidic channels for bi-directional neurochemical interaction, Journal of Neural Engineering, vol. 8, (2011), 066001

D. Fan, D. Rich, T. Holtzman, P. Ruther, J.W. Dalley, A. Lopez, M.A. Rossi, J.W. Barter, D. Salas-Meza, S. Herwik, T. Holzhammer, J. Morizio, and H.H. Yin, A wireless multi-channel recording system for freely behaving mice and rats, PLoS ONE, 2011, 6, e22033, doi 10.1371/journal.pone.0022033

C. Hassler, R.P. von Metzen, P. Ruther, T. Stieglitz, Characterization of parylene C as an encapsulation material for implanted neural prostheses, J. Biomedical Materials Research Part B: Applied Biomaterials, DOI: 10.1002/jbm.b.31584, Vol. 93B, No. 1, 2010, p. 266-274

S. Herwik, S. Kisban, A.A.A. Aarts, K. Seidl, G. Girardeau, K. Benchenane, M. B. Zugaro, S. I. Wiener, O. Paul, H. P. Neves and P. Ruther, Fabrication technology for silicon-based microprobe arrays used in acute and sub-chronic neural recording, J. Micromech. Microeng. 19 (2009) 074008 (11 pp)

J.S. Kern, S. Loeckermann, A. Fritsch, I. Hausser, W. Roth, T.M. Magin, C. Mack, M.L. Müller, O. Paul, P. Ruther and L. Bruckner-Tuderman, Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa: High Stability of Collagen VII Favors Long-term Skin Integrity, Molecular Therapy 17, 1605-1615 (30 June 2009) doi:10.1038/mt.2009.144


Research track record:

Patrick Ruther (PR) studied physics at the University of Constance, Germany, and received in 1996 his PhD in mechanical engineering from the University of Karlsruhe, Germany, on the development of a MEMS-based micro test system. Following his post-doc at the Research Center Karlsruhe on micro-optical components and system, PR joined in 1998 the University of Freiburg as a senior scientist and groupleader working on physical sensors (mechanical stress, magnetic fields, …), material and system validation, and process development. Since 2004 PR focuses on neural probes based on silicon and innovative MEMS fabrication technologies for life science applications (Kern et al. 2009), in particular neuroscientific research and human applications. He pioneered the so-called electronic depth control (EDC) probes introducing CMOS circuitry into the probes shafts enabling an unprecedented increase in the amount of recording sites per probe (Seidl et al. 2011). The probes are further equipped with micro-optical components such as thin-film LEDs (Gossler et al. 2014) or LED chips (Ayub et al., 2016) enabling a layer specific optical stimulation of neural tissue. PR has a strong expertise in leading collaborative research projects of interdisciplinary character, i.e. as technology coordinator of NeuroProbes (EC-FP6) and coordinator of NeuroSeeker (EC-FP7) targeting the next generation of neural probes with electrical and optical functionality.